manifested as long-term or super-large dose use of antibiotics, because the dose doubling of antibiotics can not prolong its action time in vivo, long-term use can lead to liver and kidney injury, hemagglutination disorder, drug rash, double infection and a series of adverse reactions. In particular, aminoglycoside antibiotics, the side effects are mainly damage to the eighth side of the brain nerve and kidney, long-term or extensive use of such drugs can damage the cochlear nerve resulting in hearing loss or deafness, damage to the vestibular nerve, cause dizziness and imbalance of balance, liver dysfunction, the body is prone to cumulative poisoning.